System Development Engineer M - F H/F - 33

TreeFrog Therapeutics is an innovative, international biotechnology company aiming to bring cell therapies to millions of patients using our C-STEM encapsulation technology, enabling large-scale amplification of iPS and differentiated cell products for patients. Using our C-STEM format, TreeFrog is currently developing multiple cell therapy programs for disease indications includingand acute liver failure. TreeFrog has also entered into a collaboration withto incorporate C-STEM in the production of iPS-derived islets for type 1 diabetes.

Find out more at our website:You will be part of the System Engineering team whose mission is to bring disruptive technological modules developed by expert scientist into functional prototypes and early development systems. You will work at the interface of technical engineering and process/bio engineering. You will be involved in the innovation and development of engineering systems and solutions. Our main technology recently released from R&D stages, being deployed for cell therapy manufacturing under GMP(Good Manufacturing Practices) is an.

You will be reporting directly to the System Engineering Team Manager.

RESPONSABILITIES

As System Development Engineering, you will be involved in developing, testing, and validating encapsulation technologies and their submodules with a strong focus on reliability demonstration. The role includes leading the design and testing of sub-modules, working collaboratively with internal teams and external stakeholders. You will design experimental plans, test methods and use statistical analysis for both prototypes and final systems to ensure system robustness and long-term performance.

Your missions will be :

1. Perform experiments of submodules for encapsulation technology (80%)

· Plan, execute and lead experimental campains of submodules prototypes, both internally and with external partners, to support the development and verification of technologies.

· Develop and implement rigorous experimental plans (DoE), test protocols, and verification methods to characterize system performance, reliability, and robustness under all operating conditions.

· Apply risk-based approaches (DFMEA) to identify and mitigate potential reliability issues early in the design process.

· Conduct stress, testing under limits, and extreme conditions to identify potential failure modes and performance boundaries.

· Analyze data using statistical and reliability tools to exctrat actionable insights and quantify confidence and performance

· Document findings in detailed technical reports and present results, recommandations, and design implication to cross-functional teams.

2. Coordinate and develop tools and test benches (20%)

· Coordinate prototype development activities with external design offices and internal stackholders.

· Together with mechanical engineering, design and build custom test benches and data acquisition systems to evaluate submodule robustness, repeatability, and long-term stability.

· Contribute to the definition of system-level reliability validation plans and statistical test strategies for new developments.